[SPINA] New trial investigates interlocking roles of TSH, FT4 and FT3

[Johannes W. Dietrich]

Results of a new trial making use of SPINA have recently been  
published in Clinical Endocrinology.
This study investigated patterns of thyroid homeostasis in 1912  
subjects with different thyroid conditions. It revealed that  
correlations between FT3, FT4 and TSH were modulated by multiple  
factors including age, body mass, thyroid volume, antibody status and  
L-T4 treatment. FT3 levels and calculated deiodinase activity (SPINA- 
GD) were significantly lower in subjects treated with levothyroxine.

The authors conclude that equilibria typical of the healthy state are  
not invariant, but profoundly altered by multiple factors, e.g. L-T4  
treatment. This study suggests the revisitation of strategies for  
treatment optimisation.



-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- --  
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-- Dr. Johannes W. Dietrich, M.D.
-- Oberarzt / Consultant Endocrinologist
-- Laboratory XU44, Endocrine Research
-- Medical Hospital I, Bergmannsheil University Hospitals
-- Ruhr University of Bochum
-- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany
-- Phone: +49:234:302-6400, Fax: +49:234:302-6403
-- eMail: "j.w.dietrich at medical-cybernetics.de"
-- WWW: http://www.thyreologie.com.de
-- WWW: http://www.uk.rub.de
-- Researcher ID: C-3498-2009
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