[SPINA] SPINA Thyr - looking backward to 2018

Mi Jan 2 23:52:06 CET 2019

Dear subscribers of the SPNA list,

in this winter I would again like to look back to interesting developments of the previous year. The SPINA methodology enjoys growing interest. More and more papers from several countries and continents demonstrated interesting physiological and clinical implications of calculated structure parameters. Therefore, I am able to present to you nine papers (apart from the fact that there may be articles that I am not aware of).

The paper by a group in South Korea demonstrated in patients suffering from Graves’ disease that thyroid’s secretory capacity (SPINA-GT) and total deiodinase activity (SPINA-GD) correlate to basal metabolic rate and that these parameters decrease during treatment [1]. This is an interesting confirmation of the physiological validity of these parameters.

As many as five papers were published by a group in Poland. The first one showed that a gluten-free diet results in increased SPINA-GT in patients with autoimmune thyroiditis – in parallel to sinking antibody titres [2]. The second study showed that in women with latent (euthyroid) autoimmune thyroiditis SPINA-GT increases due to therapy with statins (provided that the supply with vitamin D is sufficient) [3]. This effect may be caused by positive effects on autoimmune processes. Men were investigated in a third group. They were hyperthyroid, and in this population with pathological metabolism the results showed that both both SPINA-GT and SPINA-GD correlate negatively to erectile function, intercourse satisfaction, orgasmic function and sexual desire [4]. A fourth paper showed that in women with autoimmune thyroiditis substitution with vitamin D results in increases SPINA-GT. This effect is augmented by selenomethionine [5]. Similar effects were observed in men. Here selenomethionine therapy also leads to increased SPINA-GD [6].

The paper of a dutch-spanish group received considerable public interest. It showed that SPINA-GT and SPINA-GD are significantly reduced in chronic fatigue syndrome (compared to age- and sex-matched controls) [7]. Obviously, this is the correlative of type 1 thyroid allostasis, as it is also known from critically ill patients, where it is referred to as non-thyroidal illness syndrome or TACITUS.

We ourselves [8] could show that the pituitary function correlates to SPINA-GT and that this relation is modified in autoimmune thyroiditis. Obviously, both functional thyroid capacity and preferential T3 formation are essential elements for adjusting the sensitivity of central components of the feedback loop.

On the basis of these insights it is advisable to consider parameters like SPINA-GD in future studies and to include them in multivariable prediction models or in stratification strategies [9].

For 2019 new papers are in preparation – at least by our group, but perhaps by other teams, too. I also would like to point your attention to a new eBook on this topic by our group, which is available for free from  https://books.google.de/books/about/Homeostasis_and_Allostasis_of_Thyroid_Fu.html?id=Yv9qDwAAQBAJ&redir_esc=y <https://books.google.de/books/about/Homeostasis_and_Allostasis_of_Thyroid_Fu.html?id=Yv9qDwAAQBAJ&redir_esc=y> or https://www.frontiersin.org/research-topics/4262/homeostasis-and-allostasis-of-thyroid-function <https://www.frontiersin.org/research-topics/4262/homeostasis-and-allostasis-of-thyroid-function> , respectively (please click on „Download Ebook PDF“ or „Download Ebook EPUB“ on the top part of the page).

Best regards and a Happy New Year,
JWD

List of studies:

1. Kim MJ, Cho SW, Choi S, Ju DL, Park DJ, Park YJ. Changes in Body Compositions and Basal Metabolic Rates during Treatment of Graves' Disease. Int J Endocrinol. 2018 May 3;2018:9863050. doi: 10.1155/2018/9863050. PMID 29853888; PMCID PMC5960571. https://www.ncbi.nlm.nih.gov/pubmed/29853888 <https://www.ncbi.nlm.nih.gov/pubmed/29853888> https://doi.org/10.1155/2018/9863050 <https://doi.org/10.1155/2018/9863050>

2. Krysiak R, Szkróbka W, Okopień B. The Effect of Gluten-Free Diet on Thyroid Autoimmunity in Drug-Naïve Women with Hashimoto's Thyroiditis: A Pilot Study. Exp Clin Endocrinol Diabetes. 2018 Jul 30. doi: 10.1055/a-0653-7108. PMID 30060266. https://www.ncbi.nlm.nih.gov/pubmed/30060266 <https://www.ncbi.nlm.nih.gov/pubmed/30060266> https://doi.org/10.1055/a-0653-7108 <https://doi.org/10.1055/a-0653-7108>

3. Krysiak R, Szkróbka W, Okopień B. The Relationship Between Statin Action On Thyroid Autoimmunity And Vitamin D Status: A Pilot Study. Exp Clin Endocrinol Diabetes. 2018 Aug 27. doi: 10.1055/a-0669-9309. PMID 30149415. https://www.ncbi.nlm.nih.gov/pubmed/30149415 <https://www.ncbi.nlm.nih.gov/pubmed/30149415> https://doi.org/10.1055/a-0669-9309 <https://doi.org/10.1055/a-0669-9309>

4. Krysiak R, Marek B, Okopień B. Sexual function and depressive symptoms in men with overt hyperthyroidism. Endokrynol Pol. 2018 Oct 11. doi: 10.5603/EP.a2018.0069. PMID 30307028 https://www.ncbi.nlm.nih.gov/pubmed/30307028 <https://www.ncbi.nlm.nih.gov/pubmed/30307028> https://doi.org/10.5603/EP.a2018.0069 <https://doi.org/10.5603/EP.a2018.0069>

5. Robert Krysiak, Karolina Kowalcze, Bogusław Okopień. SELENOMETHIONINE POTENTIATES THE IMPACT OF VITAMIN D ON THYROID AUTOIMMUNITY IN EUTHYROID WOMEN WITH HASHIMOTO’S THYROIDITIS AND LOW VITAMIN D STATUS. Pharmacological Reports 2018, ISSN 1734-1140, https://doi.org/10.1016/j.pharep.2018.12.006 <https://doi.org/10.1016/j.pharep.2018.12.006>

6. Robert Krysiak, Witold Szkróbka, Bogusław Okopień. The effect of vitamin D and selenomethionine on thyroid antibody titers, hypothalamic-pituitary-thyroid axis activity and thyroid function tests in men with Hashimoto’s thyroiditis: a pilot study. Pharmacological Reports, 2018, ISSN 1734-1140, https://doi.org/10.1016/j.pharep.2018.10.012 <https://doi.org/10.1016/j.pharep.2018.10.012>.

7. Ruiz-Núñez B, Tarasse R, Vogelaar EF, Janneke Dijck-Brouwer DA, Muskiet FAJ. Higher Prevalence of „Low T3 Syndrome“ in Patients With Chronic Fatigue Syndrome: A Case-Control Study. Front Endocrinol (Lausanne). 2018 Mar 20;9:97. doi: 10.3389/fendo.2018.00097. PMID: 29615976; PMCID: PMC5869352. https://www.ncbi.nlm.nih.gov/pubmed/?term=Tarasse-R+2018 <https://www.ncbi.nlm.nih.gov/pubmed/?term=Tarasse-R+2018> https://doi.org/10.3389/fendo.2018.00097 <https://doi.org/10.3389/fendo.2018.00097>

8. Hoermann R, Midgley JEM, Larisch R, Dietrich JW. The role of functional thyroid capacity in pituitary thyroid feedback regulation. Eur J Clin Invest. 2018 Oct;48(10):e13003. doi: 10.1111/eci.13003. PMID: 30022470. https://www.ncbi.nlm.nih.gov/pubmed/30022470 <https://www.ncbi.nlm.nih.gov/pubmed/30022470> https://doi.org/10.1111/eci.13003 <https://doi.org/10.1111/eci.13003>

9. Hoermann R, Midgley JEM, Larisch R, Dietrich JW. Lessons from Randomised Clinical Trials for Triiodothyronine Treatment of Hypothyroidism: Have They Achieved Their Objectives? J Thyroid Res. 2018 Jul 16;2018:3239197. doi: 10.1155/2018/3239197. PMID 30174821; PMCID PMC6098896. https://www.ncbi.nlm.nih.gov/pubmed/30174821 <https://www.ncbi.nlm.nih.gov/pubmed/30174821> https://doi.org/10.1155/2018/3239197 <https://doi.org/10.1155/2018/3239197>

-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- --
-- PD Dr. med. Johannes W. Dietrich
-- Laboratory XU44, Endocrine Research
-- Medical Hospital I, Bergmannsheil University Hospitals
-- Ruhr University of Bochum
-- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany
-- Phone: +49:234:302-6400, Fax: +49:234:302-6403
-- eMail: "johannes.dietrich at ruhr-uni-bochum.de"
-- http://www.thyreologie.com.de
-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- --

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