From johannes.dietrich at ruhr-uni-bochum.de Sat Feb 24 18:16:25 2024 From: johannes.dietrich at ruhr-uni-bochum.de (Johannes W. Dietrich) Date: Sat, 24 Feb 2024 18:16:25 +0100 Subject: [SPINA] Combined with mathematical modelling, a single blood sample may be better than a complex test Message-ID: <864D0E8F-D53B-49FB-A4A1-944BD3BB4F96@ruhr-uni-bochum.de> Early diagnosis of diabetes mellitus continues to be a challenge. Established test protocols are either elaborate and expensive or of limited quality, and even the concept of prediabetes is debated. The key determinants of glucose homeostasis, beta cell function and insulin sensitivity, have low utility when assessed independently. Their combination, the dynamic disposition index, a measure of the feedback loop?s circular gain, is a more meaningful parameter for the homeostatic function. Still, its determination requires a frequently sampled oral glucose tolerance test, a complex and time-consuming procedure. An innovative approach developed by our team members in Germany, India, Singapore and the UK promises to be not only simpler but even better. It is derived from SPINA Carb, a method to assess key properties of the feedback control system based on single measurements of insulin and glucose, and on mathematical modelling. The new technique delivers a novel fasting-based disposition index (SPINA-DI), which is obtained from the reconstructed beta cell function (SPINA-GBeta) and static insulin sensitivity (SPINA-GR). Using computer simulations, we could show that the new parameter confirms a theory of dynamical compensation of insulin resistance by enhanced beta cell output in the metabolic syndrome. In a subsequent evaluation that was performed in three cohorts from the United States, Germany and India this assumption could be corroborated. In all three populations, SPINA-DI correlated with important predictors of metabolic function including the response to oral glucose tolerance testing, the disposition index according to Matsuda and DeFronzo, HbA1c fraction, waist circumference and concentrations of free fatty acids, ghrelin and adiponectin. Furthermore, SPINA-DI had higher retest reliability than other calculated markers of glucose homeostasis. For the diagnosis of diabetes, SPINA-DI had better accuracy than alternative methods including the dynamic disposition index based on frequently sampled oral glucose tolerance testing. In summary, the new fasting-based disposition index provides an inexpensive, precise and reliable measure for the performance of the feedback loop. It may complement and, in many cases, replace established methods that are more costly and laborious. Reference: Dietrich JW, Abood A, Dasgupta R, Anoop S, Jebasingh FK, Spurgeon R, Thomas N, Boehm BO. A novel simple disposition index (SPINA-DI) from fasting insulin and glucose concentration as a robust measure of carbohydrate homeostasis. J Diabetes. 2024 Jan 2. doi: 10.1111/1753-0407.13525. Epub ahead of print. PMID: 38169110. https://pubmed.ncbi.nlm.nih.gov/38169110/ -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PD Dr. med. Johannes W. Dietrich -- Diabetes, Endocrinology and Metabolism Section -- Department of Medicine I, St. Josef Hospital -- Ruhr University of Bochum -- Gudrunstr. 56, D-44791 Bochum, NRW, Germany -- Phone: +49:234:509-2311, Fax: +49:234:509-2309 -- eMail: "johannes.dietrich at ruhr-uni-bochum.de? -- ORCID 0000-0002-1185-3549 -- http://www.endokrinologie.org -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- ? Announcement: Our eBook "Thyroid Hormones and Cardiac Arrhythmia? has been published. You may want to visit http://dx.doi.org/10.3389/978-2-83250-253-2 or https://www.frontiersin.org/research-topics/16898/thyroid-hormones-and-cardiac-arrhythmia. -------------- nächster Teil -------------- Ein Dateianhang mit HTML-Daten wurde abgetrennt... URL: From johannes.dietrich at ruhr-uni-bochum.de Sat Feb 24 19:07:52 2024 From: johannes.dietrich at ruhr-uni-bochum.de (Johannes W. Dietrich) Date: Sat, 24 Feb 2024 19:07:52 +0100 Subject: [SPINA] SPINA Thyr 4.2.1 released Message-ID: <7A0EA43A-B31A-48BE-B4C8-844510EC284B@ruhr-uni-bochum.de> SPINA Thyr has been released in version 4.2.1. This new version fixes several minor bugs. It is compatible with Windows (32 and 64 bits), macOS (Intel and Apple Silicon) and several Unix and Linux variants. Both executable binaries and source code are available from: https://spina.sourceforge.net https://doi.org/10.5281/zenodo.3596049 https://doi.org/10.5281/zenodo.10700532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PD Dr. med. Johannes W. Dietrich -- Diabetes, Endocrinology and Metabolism Section -- Department of Medicine I, St. Josef Hospital -- Ruhr University of Bochum -- Gudrunstr. 56, D-44791 Bochum, NRW, Germany -- Phone: +49:234:509-2311, Fax: +49:234:509-2309 -- eMail: "johannes.dietrich at ruhr-uni-bochum.de? -- ORCID 0000-0002-1185-3549 -- http://www.endokrinologie.org -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- ? Announcement: Our eBook "Thyroid Hormones and Cardiac Arrhythmia? has been published. You may want to visit http://dx.doi.org/10.3389/978-2-83250-253-2 or https://www.frontiersin.org/research-topics/16898/thyroid-hormones-and-cardiac-arrhythmia. -------------- nächster Teil -------------- Ein Dateianhang mit HTML-Daten wurde abgetrennt... URL: