<html><head></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; ">Previous research based on SPINA and numeric simulations with SimThyr had suggested the existence of a functional TSH-T3 shunt in humans. This hypothesis was now re-evaluated in a study with 271 thyroid-healthy subjects and 86 untreated patients with thyroid autoimmune disease. The study, which has been published in the European Thyroid Journal, found a significant and nonlinear negative association between SPINA-GD and SPINA-GT, even after correction for spurious correlation. The results of this study demonstrate that the euthyroid panel doesn't follow a homogeneous pattern to produce randomly-distributed TSH concentrations and thyroid hormones, but that it forms a heterogeneous group displaying distinctly different levels of homeostatic equilibria across the euthyroid range. It also confirms earlier assumptions that the TSH-T3 shunt mediates a compensatory response, where a sinking thyroid's secretory capacity is partly offset by increasing deiodination, thus maintaining FT3 concentrations in a normal range, despite beginning hypothyroidism.<br><br>This "online first" paper is available from <a href="http://dx.doi.org/10.1159/000447967">http://dx.doi.org/10.1159/000447967</a> .<br><br>Reference:<br>Relational Stability of Thyroid Hormones in Euthyroid Subjects and Patients with Autoimmune Thyroid Disease<br>Hoermann R., Midgley J.E.M., Larisch R., Dietrich J.W.<br>Eur Thyroid J, in Press<br>doi: 10.1159/000447967<br><div>
<span class="Apple-style-span" style="border-collapse: separate; color: rgb(0, 0, 0); font-family: Helvetica; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-border-horizontal-spacing: 0px; -webkit-border-vertical-spacing: 0px; -webkit-text-decorations-in-effect: none; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; font-size: medium; "><span class="Apple-style-span" style="border-collapse: separate; color: rgb(0, 0, 0); font-family: Helvetica; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-border-horizontal-spacing: 0px; -webkit-border-vertical-spacing: 0px; -webkit-text-decorations-in-effect: none; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; font-size: medium; "><div style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; "><span class="Apple-style-span" style="border-collapse: separate; color: rgb(0, 0, 0); font-family: Helvetica; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-border-horizontal-spacing: 0px; -webkit-border-vertical-spacing: 0px; -webkit-text-decorations-in-effect: none; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; font-size: medium; "><span class="Apple-style-span" style="font-size: small; "><div><br class="Apple-interchange-newline">-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- --</div><div>-- Dr. med. Johannes W. Dietrich</div><div>-- Oberarzt / Consultant Endocrinologist</div><div>-- Laboratory XU44, Endocrine Research</div><div>-- Medical Hospital I, Bergmannsheil University Hospitals</div><div>-- Ruhr University of Bochum</div><div>-- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany</div><div>-- Phone: +49:234:302-6400, Fax: +49:234:302-6403</div><div>-- eMail: "<a href="mailto:j.w.dietrich@medical-cybernetics.de">j.w.dietrich@medical-cybernetics.de</a>"</div><div>-- <a href="http://www.thyreologie.com.de">http://www.thyreologie.com.de</a></div><div>-- GND 123571073 | VIAF 69838628 | Researcher ID C-3498-2009</div><div>-- ISNI: 0000 0000 1275 0811 | ORCID ID: 0000-0002-1185-3549</div><div>-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- --</div><div><br></div></span></span><br class="Apple-interchange-newline"></div></span><br class="Apple-interchange-newline"></span><br class="Apple-interchange-newline">
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