<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class="">As a kind of Christmas gift we released a major new version of the SPINA Functions for the statistical programming language S (including the environment R).<div class=""><br class=""></div><div class="">This new version implements SPINA Carb for the evaluation of insulin-glucose homeostasis (while providing the established markers of thyroid homeostasis as well) and is capable of calculating the secretory capacity of pancreatic beta cells (SPINA-GBeta) and insulin receptor gain (SPINA-GR). This version facilitates the statistical evaluation of carbohydrate metabolism with S scripts. The algorithms for the calculation are derived and explained in [1]</div><div class=""><br class=""></div><div class="">Version 5.0 of the SPINA Functions is available from <a href="https://sourceforge.net/projects/spina/files/SPINA for domain-specific applications/S scripts/" class="">https://sourceforge.net/projects/spina/files/SPINA%20for%20domain-specific%20applications/S%20scripts/</a> or via zenodo from <a href="https://zenodo.org/record/7479857#.Y6cI9S1XacY" class="">https://zenodo.org/record/7479857#.Y6cI9S1XacY</a> .</div><div class=""><br class=""></div><div class="">Merry Christmas and Happy Holidays,</div><div class="">JWD</div><div class=""><br class=""></div><div class=""><br class=""></div><div class="">Reference:</div><div class=""><br class=""></div><div class="">1. Dietrich JW, Dasgupta R, Anoop S, Jebasingh F, Kurian ME, Inbakumari M, Boehm BO, Thomas N. SPINA Carb: a simple mathematical model supporting fast in-vivo estimation of insulin sensitivity and beta cell function. Sci Rep. 2022 Oct 21;12(1):17659. doi: 10.1038/s41598-022-22531-3. PMID: 36271244; PMCID: PMC9587026. <a href="https://pubmed.ncbi.nlm.nih.gov/36271244/" class="">https://pubmed.ncbi.nlm.nih.gov/36271244/</a> <br class=""><br class=""><div class="">
<div dir="auto" style="text-align: start; text-indent: 0px; word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div dir="auto" style="text-align: start; text-indent: 0px; word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div style="font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);"><br class="Apple-interchange-newline">-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- --</div><div style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); letter-spacing: normal; text-transform: none; white-space: normal; word-spacing: 0px; text-decoration: none; -webkit-text-stroke-width: 0px; font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; text-align: start; text-indent: 0px;">-- PD Dr. med. Johannes W. Dietrich<br class="">-- Diabetes, Endocrinology and Metabolism Section<br class="">-- Department of Medicine I, St. Josef Hospital<br class="">-- Ruhr University of Bochum<br class="">-- Gudrunstr. 56, D-44791 Bochum, NRW, Germany<br class="">-- Phone: +49:234:509-2311, Fax: +49:234:509-2309<br class="">-- eMail: "<a href="mailto:johannes.dietrich@ruhr-uni-bochum.de" class="">johannes.dietrich@ruhr-uni-bochum.de</a>“</div><div style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); letter-spacing: normal; text-transform: none; white-space: normal; word-spacing: 0px; text-decoration: none; -webkit-text-stroke-width: 0px; font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; text-align: start; text-indent: 0px;">-- ORCID 0000-0002-1185-3549</div><div style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); letter-spacing: normal; text-transform: none; white-space: normal; word-spacing: 0px; text-decoration: none; -webkit-text-stroke-width: 0px; font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; text-align: start; text-indent: 0px;">-- <a href="http://www.thyreologie.com.de" class="">http://www.thyreologie.com.de</a><br class="">-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- —<br class=""><br class="">Announcement: Our eBook "Thyroid Hormones and Cardiac Arrhythmia“ has been published. </div><div style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); letter-spacing: normal; text-transform: none; white-space: normal; word-spacing: 0px; text-decoration: none; -webkit-text-stroke-width: 0px; font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; text-align: start; text-indent: 0px;">You may want to visit <a href="http://dx.doi.org/10.3389/978-2-83250-253-2" class="">http://dx.doi.org/10.3389/978-2-83250-253-2</a> or <a href="https://www.frontiersin.org/research-topics/16898/thyroid-hormones-and-cardiac-arrhythmia" class="">https://www.frontiersin.org/research-topics/16898/thyroid-hormones-and-cardiac-arrhythmia</a>.<br class=""><br class=""><br class=""><br class=""><br class=""></div></div></div>
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