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    <p>Hallo, leider ist da nichts abrufbar. nur ein Referenzhandbuch
      und ein Lizenztext und die Versio 4.2.0</p>
    <p>vg matthias nagel</p>
    <p><br>
    </p>
    <p><br>
    </p>
    <div class="moz-cite-prefix">Am 24.12.2022 um 15:18 schrieb Johannes
      W. Dietrich via SPINA:<br>
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      cite="mid:647EBE63-BB34-480C-9A0A-369B2006BF8F@ruhr-uni-bochum.de">
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      As a kind of Christmas gift we released a major new version of the
      SPINA Functions for the statistical programming language S
      (including the environment R).
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      <div class="">This new version implements SPINA Carb for the
        evaluation of insulin-glucose homeostasis (while providing the
        established markers of thyroid homeostasis as well) and is
        capable of calculating the secretory capacity of pancreatic beta
        cells (SPINA-GBeta) and insulin receptor gain (SPINA-GR). This
        version facilitates the statistical evaluation of carbohydrate
        metabolism with S scripts. The algorithms for the calculation
        are derived and explained in [1]</div>
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      <div class="">Version 5.0 of the SPINA Functions is available
        from <a href="https://sourceforge.net/projects/spina/files/SPINA
          for domain-specific applications/S scripts/"
          class="moz-txt-link-freetext" moz-do-not-send="true">https://sourceforge.net/projects/spina/files/SPINA%20for%20domain-specific%20applications/S%20scripts/</a> or
        via zenodo from <a
          href="https://zenodo.org/record/7479857#.Y6cI9S1XacY"
          class="moz-txt-link-freetext" moz-do-not-send="true">https://zenodo.org/record/7479857#.Y6cI9S1XacY</a> .</div>
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      <div class="">Merry Christmas and Happy Holidays,</div>
      <div class="">JWD</div>
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      <div class="">Reference:</div>
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      <div class="">1. Dietrich JW, Dasgupta R, Anoop S, Jebasingh F,
        Kurian ME, Inbakumari M, Boehm BO, Thomas N. SPINA Carb: a
        simple mathematical model supporting fast in-vivo estimation of
        insulin sensitivity and beta cell function. Sci Rep. 2022 Oct
        21;12(1):17659. doi: 10.1038/s41598-022-22531-3. PMID: 36271244;
        PMCID: PMC9587026. <a
          href="https://pubmed.ncbi.nlm.nih.gov/36271244/"
          class="moz-txt-link-freetext" moz-do-not-send="true">https://pubmed.ncbi.nlm.nih.gov/36271244/</a> <br
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                text-align: start; text-indent: 0px;">-- PD Dr. med.
                Johannes W. Dietrich<br class="">
                -- Diabetes, Endocrinology and Metabolism Section<br
                  class="">
                -- Department of Medicine I, St. Josef Hospital<br
                  class="">
                -- Ruhr University of Bochum<br class="">
                -- Gudrunstr. 56, D-44791 Bochum, NRW, Germany<br
                  class="">
                -- Phone: +49:234:509-2311, Fax: +49:234:509-2309<br
                  class="">
                -- eMail: "<a
                  href="mailto:johannes.dietrich@ruhr-uni-bochum.de"
                  class="moz-txt-link-freetext" moz-do-not-send="true">johannes.dietrich@ruhr-uni-bochum.de</a>“</div>
              <div style="caret-color: rgb(0, 0, 0); color: rgb(0, 0,
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                font-variant-caps: normal; font-weight: normal;
                text-align: start; text-indent: 0px;">--
                ORCID 0000-0002-1185-3549</div>
              <div style="caret-color: rgb(0, 0, 0); color: rgb(0, 0,
                0); letter-spacing: normal; text-transform: none;
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                font-variant-caps: normal; font-weight: normal;
                text-align: start; text-indent: 0px;">-- <a
                  href="http://www.thyreologie.com.de"
                  class="moz-txt-link-freetext" moz-do-not-send="true">http://www.thyreologie.com.de</a><br
                  class="">
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                <br class="">
                Announcement: Our eBook "Thyroid Hormones and
                Cardiac Arrhythmia“ has been published. </div>
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                font-variant-caps: normal; font-weight: normal;
                text-align: start; text-indent: 0px;">You may want
                to visit <a
                  href="http://dx.doi.org/10.3389/978-2-83250-253-2"
                  class="moz-txt-link-freetext" moz-do-not-send="true">http://dx.doi.org/10.3389/978-2-83250-253-2</a>
                or <a
href="https://www.frontiersin.org/research-topics/16898/thyroid-hormones-and-cardiac-arrhythmia"
                  class="moz-txt-link-freetext" moz-do-not-send="true">https://www.frontiersin.org/research-topics/16898/thyroid-hormones-and-cardiac-arrhythmia</a>.<br
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      <pre class="moz-quote-pre" wrap="">_______________________________________________
SPINA mailing list
<a class="moz-txt-link-abbreviated" href="mailto:SPINA@lists.ruhr-uni-bochum.de">SPINA@lists.ruhr-uni-bochum.de</a>
<a class="moz-txt-link-freetext" href="https://lists.ruhr-uni-bochum.de/mailman/listinfo/spina">https://lists.ruhr-uni-bochum.de/mailman/listinfo/spina</a>
</pre>
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