<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class="">Lieber Herr Nagel,<div class=""><br class=""></div><div class="">Sie können Version 5.0 von <a href="https://sourceforge.net/projects/spina/files/SPINA for domain-specific applications/S scripts/" class="">https://sourceforge.net/projects/spina/files/SPINA%20for%20domain-specific%20applications/S%20scripts/</a> laden.</div><div class=""><br class=""></div><div class="">Der Link enthält nur Funktionen für die statistische Programmiersprache S. Sie unterstützen die Parameter von SPINA Thyr (SPINA-GT und SPINA-GD sowie als Ergänzung TSH-Index nach Jostel und TTSI) und seit Version 5.0 zusätzlich die Parameter von SPINA Carb (SPINA-GBeta und SPINA-GR sowie ergänzend HOMA-Beta, HOMA-IR und QUICKI).</div><div class=""><br class=""></div><div class="">Eine GUI-Version folgt später. Die jetzige Version ist für die Unterstützung wissenschaftlicher Berechnungen in Studien gedacht.</div><div class=""><br class=""></div><div class="">MfG,</div><div class="">JWD<br class=""><div class="">
<div><br class="">-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- --<br class="">-- PD Dr. med. Johannes W. Dietrich<br class="">-- Diabetes, Endocrinology and Metabolism Section<br class="">-- Department of Medicine I, St. Josef Hospital<br class="">-- Ruhr University of Bochum<br class="">-- Gudrunstr. 56, D-44791 Bochum, NRW, Germany<br class="">-- Phone: +49:234:509-2311, Fax: +49:234:509-2309<br class="">-- eMail: "<a href="mailto:johannes.dietrich@ruhr-uni-bochum.de" class="">johannes.dietrich@ruhr-uni-bochum.de</a>“<br class="">-- ORCID 0000-0002-1185-3549<br class="">-- <a href="http://www.thyreologie.com.de" class="">http://www.thyreologie.com.de</a><br class="">-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- —<br class=""><br class="">Announcement: Our eBook "Thyroid Hormones and Cardiac Arrhythmia“ has been published. <br class="">You may want to visit <a href="http://dx.doi.org/10.3389/978-2-83250-253-2" class="">http://dx.doi.org/10.3389/978-2-83250-253-2</a> or <a href="https://www.frontiersin.org/research-topics/16898/thyroid-hormones-and-cardiac-arrhythmia" class="">https://www.frontiersin.org/research-topics/16898/thyroid-hormones-and-cardiac-arrhythmia</a>.<br class=""><br class=""><br class=""><br class=""></div>
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<div><br class=""><blockquote type="cite" class=""><div class="">Am 03.01.2023 um 12:04 schrieb M. Nagel <<a href="mailto:nagel@nuklearmedizin-nagel.de" class="">nagel@nuklearmedizin-nagel.de</a>>:</div><br class="Apple-interchange-newline"><div class="">
<meta http-equiv="Content-Type" content="text/html; charset=UTF-8" class="">
<div class=""><p class="">Hallo, leider ist da nichts abrufbar. nur ein Referenzhandbuch
und ein Lizenztext und die Versio 4.2.0</p><p class="">vg matthias nagel</p><p class=""><br class="">
</p><p class=""><br class="">
</p>
<div class="moz-cite-prefix">Am 24.12.2022 um 15:18 schrieb Johannes
W. Dietrich via SPINA:<br class="">
</div>
<blockquote type="cite" cite="mid:647EBE63-BB34-480C-9A0A-369B2006BF8F@ruhr-uni-bochum.de" class="">
<meta http-equiv="Content-Type" content="text/html; charset=UTF-8" class="">
As a kind of Christmas gift we released a major new version of the
SPINA Functions for the statistical programming language S
(including the environment R).
<div class=""><br class="">
</div>
<div class="">This new version implements SPINA Carb for the
evaluation of insulin-glucose homeostasis (while providing the
established markers of thyroid homeostasis as well) and is
capable of calculating the secretory capacity of pancreatic beta
cells (SPINA-GBeta) and insulin receptor gain (SPINA-GR). This
version facilitates the statistical evaluation of carbohydrate
metabolism with S scripts. The algorithms for the calculation
are derived and explained in [1]</div>
<div class=""><br class="">
</div>
<div class="">Version 5.0 of the SPINA Functions is available
from <a href="https://sourceforge.net/projects/spina/files/SPINA%20%20%20%20%20%20%20%20%20%20for%20domain-specific%20applications/S%20scripts/" class="moz-txt-link-freetext" moz-do-not-send="true">https://sourceforge.net/projects/spina/files/SPINA%20for%20domain-specific%20applications/S%20scripts/</a> or
via zenodo from <a href="https://zenodo.org/record/7479857#.Y6cI9S1XacY" class="moz-txt-link-freetext" moz-do-not-send="true">https://zenodo.org/record/7479857#.Y6cI9S1XacY</a> .</div>
<div class=""><br class="">
</div>
<div class="">Merry Christmas and Happy Holidays,</div>
<div class="">JWD</div>
<div class=""><br class="">
</div>
<div class=""><br class="">
</div>
<div class="">Reference:</div>
<div class=""><br class="">
</div>
<div class="">1. Dietrich JW, Dasgupta R, Anoop S, Jebasingh F,
Kurian ME, Inbakumari M, Boehm BO, Thomas N. SPINA Carb: a
simple mathematical model supporting fast in-vivo estimation of
insulin sensitivity and beta cell function. Sci Rep. 2022 Oct
21;12(1):17659. doi: 10.1038/s41598-022-22531-3. PMID: 36271244;
PMCID: PMC9587026. <a href="https://pubmed.ncbi.nlm.nih.gov/36271244/" class="moz-txt-link-freetext" moz-do-not-send="true">https://pubmed.ncbi.nlm.nih.gov/36271244/</a> <br class="">
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<div style="font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; caret-color: rgb(0, 0, 0);" class=""><br class="Apple-interchange-newline">
-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- --
-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- --</div>
<div style="caret-color: rgb(0, 0, 0); letter-spacing: normal; text-transform: none; white-space: normal; word-spacing: 0px; text-decoration: none; -webkit-text-stroke-width: 0px; font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; text-align: start; text-indent: 0px;" class="">-- PD Dr. med.
Johannes W. Dietrich<br class="">
-- Diabetes, Endocrinology and Metabolism Section<br class="">
-- Department of Medicine I, St. Josef Hospital<br class="">
-- Ruhr University of Bochum<br class="">
-- Gudrunstr. 56, D-44791 Bochum, NRW, Germany<br class="">
-- Phone: +49:234:509-2311, Fax: +49:234:509-2309<br class="">
-- eMail: "<a href="mailto:johannes.dietrich@ruhr-uni-bochum.de" class="moz-txt-link-freetext" moz-do-not-send="true">johannes.dietrich@ruhr-uni-bochum.de</a>“</div>
<div style="caret-color: rgb(0, 0, 0); letter-spacing: normal; text-transform: none; white-space: normal; word-spacing: 0px; text-decoration: none; -webkit-text-stroke-width: 0px; font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; text-align: start; text-indent: 0px;" class="">--
ORCID 0000-0002-1185-3549</div>
<div style="caret-color: rgb(0, 0, 0); letter-spacing: normal; text-transform: none; white-space: normal; word-spacing: 0px; text-decoration: none; -webkit-text-stroke-width: 0px; font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; text-align: start; text-indent: 0px;" class="">-- <a href="http://www.thyreologie.com.de/" class="moz-txt-link-freetext" moz-do-not-send="true">http://www.thyreologie.com.de</a><br class="">
-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- --
-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- —<br class="">
<br class="">
Announcement: Our eBook "Thyroid Hormones and
Cardiac Arrhythmia“ has been published. </div>
<div style="caret-color: rgb(0, 0, 0); letter-spacing: normal; text-transform: none; white-space: normal; word-spacing: 0px; text-decoration: none; -webkit-text-stroke-width: 0px; font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; text-align: start; text-indent: 0px;" class="">You may want
to visit <a href="http://dx.doi.org/10.3389/978-2-83250-253-2" class="moz-txt-link-freetext" moz-do-not-send="true">http://dx.doi.org/10.3389/978-2-83250-253-2</a>
or <a href="https://www.frontiersin.org/research-topics/16898/thyroid-hormones-and-cardiac-arrhythmia" class="moz-txt-link-freetext" moz-do-not-send="true">https://www.frontiersin.org/research-topics/16898/thyroid-hormones-and-cardiac-arrhythmia</a>.<br class="">
<br class="">
<br class="">
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