[Biomedical-cybernetics] Two lectures on systems biology in Munich

Johannes W. Dietrich j.w.dietrich at medizinische-kybernetik.de
Sun Jul 6 18:43:21 CEST 2008


Dear colleagues,

for those of you that are from southern Germany the following two 
lectures by Eberhard Voit that will be held in Munich may be of 
interest.

At 18:25 Uhr +0100 03.07.2008, Christoph Best wrote:
>
>Dear colleagues:
>
>sorry, I got confused in the previous email: Eberhard Voit will be
>giving two seminars in Munich.
>
>The first one on July 7:
>
>     Monday, July 7, 17:00
>
>     Eberhard Voit
>     Georgia Tech and Emory University
>
>     Mathematical Modeling of Combined Genomic and Metabolic Systems
>
>     at the LMU Gene Center in Grosshadern, Lecture Hall, Room 0.75
>
>     Host: P. Cramer. E. Mendoza, 2180 76951
>
>and the second one on July 9 at the bioinformatics colloquium, see below.
>
>
>                           Wednesday, July 9, 18:00
>
>                          Bioinformatics Colloquium
>
>
>                         Systems Biology and its Role in
>
>                   Predictive Health and Personalized Medicine
>
>                                         
>
>                           Prof. Dr. Eberhard O. Voit
>
>                   Director, Integrative BioSystems Institute
>
>                             Atlanta, Georgia U.S.A.
>
>
>                       Room no. B0 52, Theresienstr. 39
>
>                                         
>
>   Recent advances in the natural and computational sciences have made it
>   possible to study health and disease with a new and powerful arsenal of
>   molecular and computational tools. The enormous potential of these tools
>   has focused the spotlight on the possibilities of predicting health
>   processes and personalizing treatment. Bioinformaticians have admirably
>   managed the flood of biomedical data and made methods available for
>   information mining and data driven analysis. However, data and their
>   management alone will be insufficient for a comprehensive understanding
>   of how cells or organisms function and which molecular or physiological
>   changes might lead from health to disease. The reasons for the remaining
>   gap in understanding are manifold but are ultimately associated with the
>   enormous complexity of cells and organisms. A promising approach toward
>   closing the gap in understanding is the construction of integrative
>   mathematical and computational models.  With advances in hardware and
>   software as well as in systems analytical methods, these models are on
>   the brink of becoming sufficiently accurate and comprehensive to yield
>   deep insights into specific disease processes.  While the current models
>   have not yet reached this point, their potential and utility are clearly
>   visible on the horizon.  Under this premise, the presentation will
>   suggest how models can aid our thinking about health and disease beyond
>   the observation that one state is ?normal? and the other is somehow
>   abnormal and therefore diseased.  Specifically, I will define health and
>   disease simplexes, which represent the multi-factorial nature of health
>   and disease and permit the characterization of interpersonal
>   variability, genetic predisposition, life style choices, risk
>   assessments, the investigation of reversible and irreversible
>   trajectories from health to disease and back, and for assessments of
>   alternative treatment strategies. I will formalize these concepts
>   mathematically in the language of Biochemical Systems Theory, which has
>   been used in the past for a variety of analyses of biomedical systems
>   and also provided the first objective rationale for Cox?s proportional
>   hazard model and the linear-logistic disease risk model of epidemiology.
>
>Sorry again for filling your mail boxes.
>-Christoph
>--
>| Christoph Best         <best at ebi.ac.uk>           http://www.ebi.ac.uk/~best
>| European Bioinformatics Institute, Cambridge, UK             +44-1223-492649
>
>Date: Thu, 03 Jul 2008 18:25:23 +0100

Kind regards

J. W. D.

-- 
-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- --
-- Dr. Johannes W. Dietrich, M.D.
-- Medizinische Klinik I, Endokrinologie, Diabetologie und Intensivmedizin
-- Berufsgenossenschaftliches Universitaetsklinikum Bergmannsheil
-- Ruhr-Universitaet Bochum
-- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany
-- Phone: +49:234:302-6400, Fax: +49:234:302-6403
-- eMail: "j.w.dietrich at medical-cybernetics.de"
-- WWW: http://medical-cybernetics.de
-- WWW: http://www.bergmannsheil.de
-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- --



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