[SPINA] Hyperdeiodination compensates for beginning thyroid failure

[Johannes W. Dietrich]

Previous research based on SPINA and numeric simulations with SimThyr had suggested the existence of a functional TSH-T3 shunt in humans. This hypothesis was now re-evaluated in a study with 271 thyroid-healthy subjects and 86 untreated patients with thyroid autoimmune disease. The study, which has been published in the European Thyroid Journal, found a significant and nonlinear negative association between SPINA-GD and SPINA-GT, even after correction for spurious correlation. The results of this study demonstrate that the euthyroid panel doesn't follow a homogeneous pattern to produce randomly-distributed TSH concentrations and thyroid hormones, but that it forms a heterogeneous group displaying distinctly different levels of homeostatic equilibria across the euthyroid range. It also confirms earlier assumptions that the TSH-T3 shunt mediates a compensatory response, where a sinking thyroid's secretory capacity is partly offset by increasing deiodination, thus maintaining FT3 concentrations in a normal range, despite beginning hypothyroidism.

This "online first" paper is available from http://dx.doi.org/10.1159/000447967 .

Reference:
Relational Stability of Thyroid Hormones in Euthyroid Subjects and Patients with Autoimmune Thyroid Disease
Hoermann R., Midgley J.E.M., Larisch R., Dietrich J.W.
Eur Thyroid J, in Press
doi: 10.1159/000447967

-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- --
-- Dr. med. Johannes W. Dietrich
-- Oberarzt / Consultant Endocrinologist
-- Laboratory XU44, Endocrine Research
-- Medical Hospital I, Bergmannsheil University Hospitals
-- Ruhr University of Bochum
-- Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, NRW, Germany
-- Phone: +49:234:302-6400, Fax: +49:234:302-6403
-- eMail: "j.w.dietrich at medical-cybernetics.de"
-- http://www.thyreologie.com.de
-- GND 123571073 | VIAF 69838628 | Researcher ID C-3498-2009
-- ISNI: 0000 0000 1275 0811 | ORCID ID: 0000-0002-1185-3549
-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- --





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